To address the health and well-being of mice and rats by ensuring safe breeding practices and population densities. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 Both cases require work in higher biosafety level containments, additional screening methods and special guidelines for the handling and restraint of such animals. Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to comment on a system that we consider to be scientifically flawed and are fundamentally opposed to. Abstract. The caging choices for conventionally housed mice were filter-topped shoebox cages (81%), open cages (52%), and ventilated caging systems (48%). Justification for housing situations that fall outside of the normal must be approved in the IACUC animal use protocol. endobj GUIDELINES FOR RATS AND MICE . Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. Limiting breeding cage occupancy reduces the incidence of morbidity and mortality due to overcrowding. An exception to a Policy must be described and justified in the Animal Protocol and approved by the full IACUC at a convened monthly meeting. endobj 2800 Plymouth Road GUIDANCE & OVERSIGHT Email: ulam-questions@umich.edu. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. the draft guidelines for the housing of mice in scientific institutions. 3 0 obj Fax: (734) 936-3235 <>>> 11 However, the observed effects can depend on the sex and strain of the animals on the one hand, and on the cage and laboratory environment on the other hand. ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. x��Zmo�� ���'X+�(�X�$�w[����i��[���Z>EN����BR�m�B�=G���yy晡��o����_n?݉��Z��݊��db�ry���E�đ1�OQ��,uTj�e2�Z,�]^\}�V�k-������[!�����(�2���,U�Tf�LYb*�Ab,��Ϗ�����?�����O�NGq�t)���,_����/�ٮ�����|���~l�5Ic\Px��be��@�jjD�4��b��tDHRFI6E�"�$$���ڮŬ�.��e>"1�"��w`�t&~���v;_���j����m.�l9_�Y��ŬCf��H�P��Z��.ӨH�����'�>��z��b.��_������#�T����Qm���!��n�4+���}�'j��L���}�I�(K���m��>�P��䈛�"�5�)⥋��m������}P�1?��?���Ͽ����{�7:�@"a�,Gl��P�h���U���(�JT��H=�XN���(/�H��T�2��|�H9Ud�D��$2�(2-e�؈���V �@��$>�`wݻA� Animal Care & Use Office (ACUO) No. Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions (PDF|309.3 KB) Guideline No. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 October 2010). Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to 412 Victor Vaughan if housed in standard #3 rat caging. Investigators must submit a BUworks Internal Service Request (ISR) for per diems and for special service charges prior to placing animal orders. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Guidelines for Transgenic Research. Guidelines on the Care and Use of Animals for Scientific Purposes, which has been developed by theNational Advisory Committee For Laboratory Animal Research (NACLAR), is a national guide which establishes the best practices in the use and care of animals for scientific purposes. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. These rodents are social species and should be housed together, unless scientifically justified for individual housing. Institutions using mice for scientific purposes are responsible for meeting recommendations of the institution’s Animal Ethics Committee to ensure that facilities for the housing and care of mice are appropriate to the maintenance of well­being and health of the mice. Guidelines for the Social Housing and Environmental Enrichment of Laboratory Rodents and Rabbits The University of Texas at Austin . GUIDELINES FOR RATS AND MICE . Current guidelines recommend housing mice in social groups as they are highly social animals, however, aggression and fighting can occur between group-housed males leading to injuries and potentially death. Deviation from Guide should statement according to a locally established performance standard. Rats can be bred in the following conditions: Separate male before parturition if caging is <212 square inches, e.g. Modifications of cages for mice usually consist of providing material for nest building and structures which can serve as hiding places and/or for climbing. The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. 2 0 obj Institutional Animal Care and Use Committee . Exceptions to this guideline require prior IACUC approval. Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. It establishes minimum standards for the housing and care of these animals under the Prevention of Cruelty to Animals Act 1986 (The Act) and … cage ("standard" rat cage). OLAW FAQ G10, Guide pp 6-7. However, rats and mice are social animals; and individual housing constitutes a stressful situation. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. There is wide agreement in the scientific community that advances in laboratory animal health have enhanced the reliability of animal-based research. GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS (2012) Cached. Ann Arbor, MI 48109 2, 6, 9, 20, 24 It has also been shown to undergo extraintestinal replication as well. However, the thermoneutral zone of mice is between 26°C and 34°C (79–93°F) and therefore they may experience cold stress in the laboratory unless nesting material is provided for them to regulate their body temperature and the microclimate … Appendix A of the Council of Europe (2009) in the Convention for the protection of vertebrate animals used for experimental and other scientific … Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. ANZCCART 2000 Instead, the author would cite animal housing guidelines such as those made available by their own institutions or by the NIH. The NACLAR Guidelines set out the responsibilities of Pages 83. animals for scientific purposes. We have reviewed 40 studies carried out between 1987 and 2000, in which preferences as well as the effect of housing modifications have been studied. Federal guidelines mandate the following minimum IACUC membership requirements for organizations that receive funding from PHS and utilize animals regulated by the AWA: a veterinarian, scientist experienced in animal research, person whose primary concerns are in a non-scientific area, and person who is unaffiliated with the organization. Males from different litters can be combined within seven days of weaning, only if age difference is 7 days apart or less. This does not apply to: Littermates that have been cage mates since birth. Keyphrases. The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are … A.L Hargreaves. <> The NACLAR Guidelines set out the responsibilities of all the parties involved in the care and use of animals for scientific purposes, in accordance with widely accepted scientific, ethical and legal principles. Housing in stable, compatible groups - it is important to take into account sex, age, reproductive condition, familiarity, prior group housing experience when grouping the animals. This does not apply to: Littermates that have been cage mates since birth. Cage sizes recommended in current European guidelines on accommodation for laboratory animals are preferably based on scientific evidence, but where this is lacking or insufficient, recommendations are also based on best practice. Guide to the Care and Use of Experimental Animals, Volume 1 and 2, Canadian Council on Animal Care. With a physical land area of just over 700 square kilometers and a population of around 5.4 million people, this densely populated island has abundant tropical flora, parks, and g… Based on data from Guidelines for the housing of Mice in Scientific Institutions, 2012, the consumption of mice feed range from 4-8 grams/day and water consumption 5-8 ml/day (Fawcett, 2013). Some strains are more aggressive than others, and fight regardless of the age at combination. Basic requirements for good rodent housing and husbandry are given in the table below. Enclosures designed to cause minimum disturbance to the animals. Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. Canadian Council on Animal Care. The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. Generally, in light of mice being gregarious animals, it is recommended to avoid individual housing whenever possible. See Guidelines for Documenting Scientific Justification for Exceeding Cage Densities for details on required data. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. The IACUC acknowledges that some specialized genetically modified lines may require more than 2 adults and 1 litter in the breeding cage to facilitate adequate production. The total cholesterol content of mice measured after 14 days of maintenance in the four study groups. To ensure reproducibility and reduce variability, institutions have moved toward housing mice in barrier facilities and maintaining colonies in a specific pathogen-free (SPF) status. the draft guidelines for the housing of mice in scientific institutions. Trio breeding SOP with local performance measures to house mice in solid bottom cages with 71 in2 floor space. The normal total cholesterol level is 26.0-82.4 mg/dl. 4 0 obj Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. Use a clean cage when combining males from different litters to prevent territorial behavior. Forty-one percent of institutions reported housing 0-20% of their mice under conventional conditions. Therefore, it is unclear why housing many laboratory mice (>4), instead of one-or-two per cage, with the improper use/reporting of clustered-data statistics, abound in the literature. SCIENTIFIC PURPOSES I - HOUSING AND CARE THE UNIVERSITIES FEDERATION FOR ANIMAL WELFARE ' "A: GUIDELINES ON THE CARE OF LABORATORY ANIMALS AND THEIR USE FOR SCIENTIFIC PURPOSES I. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 14 - 1 March 1999 Guidelines for the Care and Housing of Dogs in Scientific Institutions Animal Welfare Unit, NSW Agriculture, Locked Bag 21, Orange NSW 2800 Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9264 9533 Fax (02) 9264 9632 3 1. This review should begin no later than October 1, 2020. 8 Epizootic diarrhea of infant mice virus (EDIM) is commonly used as a generic name for all mouse rotaviruses. No. endobj There is no doubt that the housing conditions have a robust influence on the behavior and physiology of laboratory mice. 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