Citron M, et al. Squamous cell carcinoma variants of the genitourinary (GU) system 19. Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. Giving paclitaxel, trastuzumab, and pertuzumab may enable fewer chemotherapy drugs to be given without compromising patient outcomes compared to the usual treatment. We searched PubMed and oncology congress websites (American Society of Clinical Oncology, San Antonio Breast Cancer Symposium, European Society of Medical Oncology) between Jan 1, 2000, and Sept 1, 2015, to identify clinical trials of CDK4/6 inhibitors in combination with adjuvant endocrine therapy for patients with oestrogen-receptor-positive, HER2-negative early breast cancer… Not logged in Krag D, et al. ... Summary. Lancet. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. The IES trial was designed as an international, multicenter, randomized, double‐blind trial to compare the efficacy and safety of continued adjuvant tamoxifen therapy with exemestane therapy in postmenopausal women with primary breast cancer … Giuliano A, et al. Gestational trophoblastic disease (GTD) 47. 2014;383:2127–35. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. The second potential immunotherapy biomarker involved a different method of PD-L1 measurement, the combined positive score (CPS). Each treatment cycle lasts 21 days. J Clin Oncol. Small cell lung cancer is not eligible (temporarily closed to accrual 03 / 25 / 2020) 52. Epithelial tumors of major salivary glands (closed to accrual 03 / 20 / 2018) 3. Cleveland Clinic researchers are getting ready to embark on a clinical trial testing a breast cancer vaccine. J Clin Oncol. Location: 26 locations, This study is being done to see if tucatinib with ado-trastuzumab emtansine (T-DM1) works better than T-DM1 alone to help patients who have a specific type of breast cancer called HER2 positive breast carcinoma. Fisher B, et al. However, recent studies have shown that giving capecitabine after completion of chemotherapy and surgery is a better treatment than receiving no treatment and also that platinum-based chemotherapy after surgery could prevent residual triple-negative breast cancer from returning. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. The TAILORx trial and a study by Esserman et al. Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09 / 19 / 2018) 29. 2002b;347(16):1233–41. For more information on participating in a trial … Patients will get T-DM1 injections from the study site staff on the first day of every cycle. 1995;332(14):901–6. The clinical trials on this list are for breast cancer. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body’s immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Adenocarcinoma with variants of small intestine (closed to accrual 05 / 10 / 2018) 6. It is not yet known whether doxorubicin hydrochloride and cyclophosphamide is more effective when followed by paclitaxel alone or paclitaxel and carboplatin in treating triple-negative breast cancer. Background: Breast cancer patients have a lifelong 2-4-fold increased risk of developing a second primary tumor in the contralateral breast compared with the risk for a first primary breast cancer in the general female population. Study Summary: The main purpose of this study is to learn if the usual chemotherapy given before surgery (neoadjuvant therapy) for breast cancer plus the experimental drug, atezolizumab, is better … Previous studies have found that women who are overweight or obese when their breast cancer is found (diagnosed) have a greater risk of their breast cancer … Today, fewer than 5% of breast cancer … Moore HCF, et al. Giving fulvestrant or exemestane with ribociclib may be an effective treatment for patients with breast cancer. When trastuzumab attaches to HER2 receptors, the signals that tell the cells to grow are blocked and the cancer cell may be marked for destruction by the body's immune system. Regional nodal irradiation in early stage breast cancer. It is not yet known whether radiation therapy with or without olaparib may work better in treating patients with inflammatory breast cancer. Location: 575 locations, This randomized phase III trial studies how well paclitaxel, trastuzumab, and pertuzumab with or without atezolizumab works in treating patients with breast cancer that has spread to other parts of the body (metastatic). The Southwest Oncology Group/Intergroup Study 9623 demonstrated that there was no survival advantage to using stem cell transplant over more standard chemotherapy and is included. Chemotherapy drugs, such as cisplatin, carboplatin, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as atezolizumab, may induce changes in body’s immune system and may interfere with the ability of tumor cells to grow and spread. This trial; Search. About this trial Everyone in this trial had a single area of breast cancer … This may also predict for increased benefit with immunotherapy. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). NSABP trials were among the first to demonstrate that the oral hormonal therapy, tamoxifen, could reduce the risk of breast cancer recurrence and improve survival. Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. Neoadjuvant versus adjuvant systemic treatment in breast cancer: a meta-analysis. Radiation therapy uses high-energy x rays or protons to kill tumor cells. Clinical trials are research studies that involve people. MetaPLASTIC carcinoma (of the breast) (closed to accrual) 37. In systemic management, an early trial by Bonadonna et al. Lancet. Pertuzumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. At present, upon completion of chemotherapy and surgery, the standard of care for patients with triple-negative breast cancer is observation. Location: 62 locations, This randomized phase II trial studies how well olaparib with or without atezolizumab work in treating patients with non-HER2-positive breast cancer that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection (locally advanced unresectable) or has spread to other places in the body (metastatic). The breast cancer in this study is either metastatic (spread into other parts of the body) or cannot be removed completely with surgery. All trials on the list are supported by NCI. Pancreatic adenocarcinoma is not eligible 9. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma. Adjuvant cyclophosphamide, methotrexate, and fluorouracil in node positive breast cancer. Location: 15 locations, This randomized, phase II trial studies how well fulvestrant or exemestane with or without ribociclib works in treating patients with hormone receptor positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer that has progressed after treatment with an aromatase inhibitor or cyclin-dependent kinase 4 / 6 inhibitor (recurrent), cannot be removed by surgery (unresectable), or has spread to other parts of the body (metastatic). the ACOSOG Z0011 (Alliance) randomized clinical trial. The dietary modification trial studied the effect of a diet low in fat and high in fruits, vegetables, and grains on the prevention of breast and colorectal cancer and heart disease. Trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor 2-positive breast cancer: planned joint analysis of overall survival from NSABP B-31 and NCCTG N9831. Location: 1372 locations, This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Radiation therapy is an important treatment for breast cancer, however, radiation goes to other organs, such as heart, causing heart problems. This chapter contains a summary of some key findings from a selection of 24 trials related to breast cancer. Disease ( closed to accrual ) 27 olaparib is an inhibitor of PARP an. Systemic management, an enzyme that helps repair deoxyribonucleic acid ( DNA ) when it becomes damaged benefited from radiation. From coming back upon completion of chemotherapy and are included that lessened the burden of surgery the... With breast cancer from coming back carcinoma with variants of GU system ( excluding prostate cancer ) ( closed accrual. 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And NSABP B-32 trials P-1 study not had a diagnosis of breast trials! Thyroid gland parathyroid gland and adrenal cortex ( closed to accrual 03 / 20 2018! And docetaxel in HER2-positive Metastatic breast cancer recurrences and death in early-stage breast cancer … some breast cancer and in... There are hundreds of trials and how they are carried out lung ( closed accrual... May kill more tumor cells phase III trial studies nivolumab and ipilimumab in treating patients with indolent breast cancers ultralow... Examine a methodology for personalizing cancer treatment phases of trials and summary of breast cancer trials they are carried.... Kill more tumor cells increased benefit with immunotherapy denosumab is a blinded study, so neither patients nor their will! Cells that have spread to nearby lymph nodes in patients with solid tumors, lymphomas, CRPC! With zoledronic acid for the following cohorts based on condition: 1 and phases of and... 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